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Risk Factors for Persistent Problems Following Whiplash Injury: Results of a Systematic Review and Meta-analysis

DM Walton, J Pretty, JC MacDermid, RW Teasell

STUDY DESIGN: Systematic review and meta-analysis. BACKGROUND: Whiplash-associated disorder (WAD) is the most common reported injury following motor vehicle accident. Evidence for prognosis and intervention are difficult to interpret due to differences in inception times, outcomes used, and sample heterogeneity. METHODS: An extensive literature search was conducted to identify published studies of prognosis following whiplash. Rigorous inclusion criteria were applied to allow for meaningful results to be drawn. Data were extracted, transformed where necessary, and pooled to allow estimation of the odds ratio for any factor with at least 3 data points in the literature.

RESULTS: From 11 cohorts (n = 3193), 25 factors were identified with at least 3 data points in the existing literature. Of these, 9 were found to be significant predictors based on the odds ratio and confidence limits: no postsecondary education, female gender, history of previous neck pain,baseline neck pain intensity greater than 55/100, presence of neck pain at baseline, presence of headache at baseline, catastrophizing, WAD grade 2 or 3, and no seat belt in use at time of collision. Neck pain intensity, WAD grade, headache, and no postsecondary education were robust to publication bias.

CONCLUSIONS: Using a rigorous process for the identification and extraction of data from a homogenous subset of the prognostic WAD literature, we were able to identify several factors for which information is easy to collect clinically and could provide clinicians with a good sense of prognosis following whiplash injury. LEVEL OF EVIDENCE: Prognosis, level 1a.

J Orthop Sports Phys Ther 2009;39(5):334-350, Epub 18 July 2008. View Full Article

doi:10.2519/jospt.2009.2765

Filed under: Cervical, Prognosis, Whiplash Injuries , , , ,

Hypoesthesia Occurs in Acute Whiplash Irrespective of Pain and Disability Levels and the Presence of Sensory Hypersensitivity

Chien, Andy; Eliav, Eli; Sterling, Michele

Objectives: In contrast to the increasing knowledge of the sensory dysfunction involved in chronic whiplash associated disorders, the use of comprehensive quantitative sensory testing in the acute stage of the condition is sparse. In this study, we sought to investigate the presence of sensory hypoesthesia in participants with acute whiplash injury.

Methods: Fifty-two volunteers within 4 weeks after a motor vehicle accident and 31 healthy asymptomatic volunteers were recruited for this study. We classified our cohort into either a “high-risk” (n=17; signs associated with poor recovery including Neck Disability Index scores >30, cold and mechanical hyperalgesia, heightened brachial plexus provocation test responses) or “low-risk” group (without these signs). Detection thresholds to electrical, thermal, and vibration stimuli measured in lower cervical nerve root innervation zones and psychologic distress and posttraumatic stress symptoms were compared between the groups using multivariate analysis of covariance.

Results: Both the high-risk and low-risk groups exhibited significant elevation in sensory detection when compared with controls (P<0.05). There was no difference in detection thresholds between the 2 whiplash groups, except for electrical detection which was greater in the high-risk group (P>0.05). Both groups were psychologically distressed.

Discussion: Our findings demonstrate generalized hypoesthesia in acute whiplash associated disorders suggesting adaptive central nervous system processing mechanisms are involved, regardless of pain and disability. The elevated levels of psychologic distress seen in both groups may also play a role.

Clinical Journal of Pain. November/December 2008. Vol. 24. No. 9. Pp. 759-766.

Full text available in through MTABC member only website under the research tab and then library.

Filed under: Cervical, Spine, Whiplash Injuries

The Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders: Executive Summary

Haldeman, S; Carroll, L; Cassidy, J D; Schubert, J; Nygren, Å

This Task Force consisted of a 5-member Executive Committee, a 13-member Scientific Secretariat, a 17-member Advisory Committee, and 18 research associates and graduate students. Committee members originated from 9 countries and represented 19 clinical and scientific disciplines or specialties. The Task Force was affiliated with 8 collaborating universities and research institutes in 4 countries, and 11 professional organizations agreed to become nonfinancial sponsors.

Key Findings From the Task Force

Epidemiology of Neck Pain

* Most people can expect to experience some neck pain in their lifetimes, although for the majority, neck pain will not seriously interfere with normal activities.

* Depending on the case definitions used, the 12-month prevalence of neck pain ranged from 12.1% to 71.5% in the general population, and from 27.1% to 47.8% in workers. However, neck pain with associated disability was less common: 12-month prevalence estimates ranged from 1.7% to 11.5% in the general population.

* Each year, between 11% and 14.1% of workers reported being limited in their activities because of neck pain. Neck pain was common in all occupational categories, and the results of the Ontario cohort study suggest that worker’s compensation data significantly underestimate the burden of neck pain in workers.

* The number of persons seeking health care in emergency rooms for traffic-related Whiplash-associated disorders (WAD) has been increasing over the past 3 decades.

Risk Factors for Neck Pain

* Analysis of risk factors for neck pain suggest that this disorder has a multifactorial etiology. Nonmodifiable risk factors for neck pain included age, gender, and genetics. There is no evidence that common degenerative changes in the cervical spine are a risk factor for neck pain.

* Modifiable risk/protective factors for neck pain include smoking, exposure to environmental tobacco, and physical activity participation. In the workplace high quantitative job demands, low social support at work, sedentary work position, repetitive work, and precision work increased the risk of neck pain. However, there is a lack of evidence that workplace interventions were effective in reducing the incidence of neck pain in workers.

* Eliminating insurance payments for pain and suffering, and improving benefits disability costs were both associated with a lower incidence of whiplash claims and faster recovery from symptoms. Devices aimed at limiting head extension during rear-end collisions were found to have a preventive effect.

Course and Prognosis

* Most people with neck pain do not experience a complete resolution of symptoms. Between 50% and 85% of those who experience neck pain at some initial point will report neck pain again 1 to 5 years later. These numbers appear to be similar in the general population, in workers and after motor vehicle crashes.

* The prognosis for neck pain also appears to be multifactorial. Younger age was associated with a better prognosis, whereas poor health and prior neck pain episodes were associated with a poorer prognosis. Poorer prognosis was also associated with poor psychological health, worrying, and becoming angry or frustrated in response to neck pain. Greater optimism, a coping style that involved self-assurance, and having less need to socialize, were all associated with better prognosis.

* Specific workplace or physical job demands were not linked with recovery from neck pain. Workers who engaged in general exercise and sporting activities were more likely to experience improvement in neck pain. Postinjury psychological distress and passive types of coping were prognostic of poorer recovery in WAD. There is evidence that compensation and legal factors are also prognostic for poorer recovery from WAD.

Assessment of Neck Pain

* The assessment for fracture in the emergency room and the diagnosis of neck pain with radiculopathy are of value, but there is little evidence that diagnostic procedures for neck pain without severe trauma or radicular symptoms have validity and utility.

* Screening protocols to alert low-risk patients with blunt trauma to the neck have high predictive values in detecting cervical spine fracture. Computerized tomography scan has better validity and utility in cervical trauma for high-risk or multi-injured patients. The clinical physical examination is more predictive at excluding a structural lesion or neurologic compression than at diagnosing any specific etiologic condition in patients with neck pain. All other assessment tools such as electrophysiology, imaging, injections, discography, functional tests, and bloods test lack validity and utility.

* Reliable and valid self-assessment questionnaires given to neck pain patients can provide useful information for management and prognosis.

* The finding of degenerative changes on imaging has not been shown to be associated with neck pain.

Treatments for Neck Pain (Noninvasive and Invasive)

* A number of nonsurgical treatments appeared to be more beneficial than usual care, sham, or alternative interventions but none of the active treatments were clearly superior to any other in the short or long term. Educational videos, mobilization, manual therapy, exercises, low-level laser therapy, and perhaps acupuncture appeared to have some benefit. For both WAD and other neck pain without radicular symptoms, interventions that focused on regaining function and returning to work as soon as possible were relatively more effective than interventions that did not have such a focus.

* There is evidence for short-term symptomatic improvement of radicular symptoms with epidural or selective root injections with corticosteroids, but these treatments did not appear to decrease the rate of open surgery.

* Evidence is lacking to support intra-articular steroid injections or radiofrequency neurotomy. It is not clear from the evidence that long-term outcomes are improved with the surgical treatment of cervical radiculopathy compared with nonoperative measures. However, relatively rapid and substantial relief of pain and impairment in the short term (6-12 weeks after surgery) after surgical treatment appears to have been reliably achieved.

* Early results from trials of cervical disc arthroplasty appear to show 1- to 2-year outcomes for radicular symptoms that are similar to outcomes for anterior fusion surgery. There is no evidence to support the use of cervical disc arthroplasty in patients with neck pain who do not have primary radicular pain.

Decision Analysis Study Findings

* Quality of life years (QALYs) associated with standard NSAIDs, Cox-2 NSAIDs, exercise, manipulation, and mobilization were compared in a decision-analytic model. None of the active treatments was found to be clearly superior to any other in the short or long term when estimates of the course of neck pain, adverse event risks, treatment effectiveness and risk, and patient-preferences for health outcomes were considered.

A New Conceptual Model for Neck Pain

The Neck Pain Task Force proposes a new conceptual model for the course and care of neck pain. The model is centered on persons with neck pain or who are at risk for neck pain. The model describes neck pain as an episodic occurrence over a lifetime with variable recovery between episodes. It outlines the options available to deal with neck pain; the factors that determine available options, choices, and consequences; and the short- and long-term impacts of neck pain.

A New Classification System for Neck Pain

For the subset of individuals who seek clinical care, the Neck Pain Task Force recommends a 4-grade classification system of neck pain severity that is intended to help in the interpretation of scientific evidence. The new system will also help people with neck pain, researchers, clinicians, and policy makers in framing their questions and decisions:

* Grade I neck pain: No signs or symptoms suggestive of major structural pathology and no or minor interference with activities of daily living; will likely respond to minimal intervention such as reassurance and pain control; does not require intensive investigations or ongoing treatment.

* Grade II neck pain: No signs or symptoms of major structural pathology, but major interference with activities of daily living; requires pain relief and early activation/intervention aimed at preventing long-term disability.

* Grade III neck pain: No signs or symptoms of major structural pathology, but presence of neurologic signs such as decreased deep tendon reflexes, weakness, and/or sensory deficits; might require investigation and, occasionally more invasive treatments.

* Grade IV neck pain: Signs or symptoms of major structural pathology, such as fracture, myelopathy, neoplasm, or systemic disease; requires prompt investigation and treatment.

When choosing treatments to relieve grades I and II neck pain, patients and their clinicians should consider the potential side effects and personal preferences regarding treatment options.

Filed under: Cervical, Exercise therapy, Manual therapy, Patient education, Spine, Whiplash Injuries ,

A Distinct Pattern of Myofascial Findings in Patients After Whiplash Injury

Ettlin T, Schuster C, Stoffel R, Brüderlin A, Kischka U

Objective: To identify objective clinical examinations for the diagnosis of whiplash syndrome, whereby we focused on trigger points. This was a cross-sectional study with 1 measurement point.

Results: Forty (85.1%) of the patients with whiplash had positive trigger points in the semispinalis capitis muscle. The patients with whiplash had a significantly higher prevalence of positive trigger points in the semispinalis capitis muscle than any of the control groups (P<.05). For the other examined muscles, the prevalence of trigger points in the patients with whiplash did not differ significantly from the patients with fibromyalgia or nontraumatic chronic cervical syndrome. It did differ from the patients with endogenous depression and the healthy controls.

Conclusions: Patients with whiplash showed a distinct pattern of trigger point distribution that differed significantly from other patient groups and healthy subjects. The semispinalis capitis muscle was more frequently affected by trigger points in patients with whiplash, whereas other neck and shoulder muscles and the masseter muscle did not differentiate between patients with whiplash and patients with nontraumatic chronic cervical syndrome or fibromyalgia.

Archives of Physical Medicine and Rehabilitation

Volume 89, Issue 7, Pages 1290-1293 (July 2008)

doi:10.1016/j.apmr.2007.11.041

Filed under: Cervical, Spine, Trigger points, Whiplash Injuries

 

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